Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy
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چکیده
منابع مشابه
Increased susceptibility to kainic acid-induced seizures in Engrailed-2 knockout mice.
The En2 gene, coding for the homeobox-containing transcription factor Engrailed-2 (EN2), has been associated to autism spectrum disorder (ASD). Due to neuroanatomical and behavioral abnormalities, which partly resemble those observed in ASD patients, En2 knockout (En2(-/-)) mice have been proposed as a model for ASD. In the mouse embryo, En2 is involved in the specification of midbrain/hindbrai...
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Epilepsy is a neurological disorder with recurrent unprovoked seizures as the main symptom. Of the coumarin derivatives in Angelica gigas, decursin, a major coumarin component, was reported to exhibit significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells. This study served to investigate the effects of decursin on a kainic a...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2020
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2020.105100